So way back in 2014 a really interesting paper came out about a family of bacteria called Christensenellaceae, which was found to be the most heritable group in the human gut microbiome. Furthermore this group (represented by Christensenella minuta) was furthermore associated with low BMI. Most intriguingly, mouse work demonstrated that the injection of cultured …
Human space exploration beyond Earth and Moon is a declared goal of NASA, ESA, Roscosmos and other space-faring agencies, with human Mars mission envisioned in the near future. One of the major challenges of the mission is protecting the human crew from illness and infection caused by harmful biological contaminants. To evaluate these challenges in …
Maria Gloria Dominguez-Bello gave a talk at UC Davis on March 11, 2019. This talk was part of the Storer Lectureship in Life Sciences series. Her talk was on “The Human Microbiome in an Age of Disruptive Change” and it was really quite good. I live Tweeted the talk and if you are interested the …
Just got pointed to this paper by Paula Olsiewski. Not necessarily a fan of another “-ome” word, but this seems like a really interesting study where they did intensive monitoring of environmental exposures of a few people over time. Abstract below: Human health is dependent upon environmental exposures, yet the diversity and variation in exposures …
One of the hurdles in linking microbial ecology with building science has been incorporating quantitative information about the microorganisms encountered in indoor environments, mainly because the standard high-throughput amplicon approach for community analysis is semi-quantitative, at best. Over the summer, there was a Twitter conversation related to this topic. My take-away from this (what I view …
I recently spent a weekend visiting a friend out of state and quickly came to realize that he rarely washed his hands. Before eating? No. After the gym? No. Even after going to the bathroom…and not just urination. No washing! I was disgusted and could not convince him of the same. How could an educated …
Question of the day. Where do we draw the line in terms of privacy when sampling sewer systems? I have had some major concerns about microbiome studies using sewer system samples in the past. And of course people are trying to use sewer system studies to look at all sorts of other epidemiology related data. …
We recently published a method to normalize data that corrects for batch effects and allows for pooling of raw data across studies. In this post, I want to discuss more about the important (but potentially confusing) aspect of our method, where we add noise to the zeros before performing the normalization. I’ve gotten a few …
The Metcalf lab at Colorado State University is seeking a microbiome bioinformatics postdoctoral scientist. The scientist will analyze multi-omics data sets, including but not limited to: amplicon sequencing data, shotgun metagenomics data, and metabolomics data. Min. reqs. include: Ph.D. in bioinformatics, ecology, microbiology or similar field. Proficient in coding languages (Python preferred). Demonstrated knowledge of …
New paper of interest:: Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial Plasmids Conferring Carbapenem Resistance Weingarten RA, Johnson RC, Conlan S, Ramsburg AM, Dekker JP, Lau AF, Khil P, Odom RT, Deming C, Park M, Thomas PJ, NISC Comparative Sequencing Program, Henderson DK, Palmore TN, Segre JA, Frank KM. 2018. Genomic analysis …